To protect the rights and interests of animals, PROYA minimizes the use of laboratory animals in the product development process and actively sets up and uses alternative methods. The Company also uses risk assessment and other scientific methods to replace animal testing as long as they are allowed by regulations and product safety is ensured.
PROYA uses a range of alternative methods to ensure the safety of its products, including 3D artificial skin model, ex vivo animal organ model, characteristic cell and microbial model, and other non-animal testing models. The Company conducts safety assessments for various toxicological endpoints of cosmetic raw materials such as potential skin irritation, eye irritation, sensitization, phototoxicity and genotoxicity, and performs further clinical applicability assessments based on the results of in vitro tests to ensure the safety of cosmetic raw materials and products.
In addition, the Company provides active support to and participates in the technological innovation of artificial skin and standards development related to animal testing alternatives, with a view to promoting the improvement and optimization of experimental technologies and methods in the Chinese cosmetics industry. In 2020, PROYA took a stake in Regenovo Biotechnology Co., Ltd. to establish the "Joint Experimental Center for High Throughput 3D Printing of Asian Skin Model" with a purpose to carry out research and development of artificial skin experimental technology.
Meanwhile, PROYA brings domestic cosmetics toxicology testing in line with international standards in order to promote the development of animal substitution testing in China. Upholding the principles of zero cruelty and "3R" (Reduction, Replacement and Refinement) for experimental animals, PROYA has partnered with Zhejiang Food and Drugs Inspection and Research Institute, China Association of Fragrance Flavour and Cosmetic Industries (CAFFCI), Zhejiang Health Products & Cosmetics Industry Association and other organizations to set up a number of group standards for animal testing alternatives. Among others, the In vitro test method for eye irritation test of hair-dyeing cosmetics - bovine corneal opacity and permeability test, in vitro test method for eye irritation test of eye cream cosmetics - vascular test of chick embryo chorioallantoic membrane, in vitro test method for skin irritation test of cream cosmetics - in vitro irritation test of reconstructed skin model, in vitro test method for skin metamorphosis test of hair-dyeing cosmetics - human Cell Line Activation Test (h-CLAT), and in vitro test method for skin metamorphosis of blemish whitening cosmetics - human Cell Line Activation Test (h-CLAT) have been released by Zhejiang Health Products & Cosmetics Industry Association on the national group standard information platform and have been officially implemented.
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